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CD40 Ligand Protein (CD40LG) (Soluble)

Name: CD40 Ligand Protein (CD40LG) (Soluble)
SKU: ABIN2469037
Price: 345.13 EUR
Availability: InStock

Protéine Recombinant CD40 Ligand exprimée dans Escherichia coli (E. coli).

N° du produit ABIN2469037

Aperçu rapide pour CD40 Ligand Protein (CD40LG) (Soluble) (ABIN2469037)

Antigène

Voir toutes CD40 Ligand (CD40LG) Protéines

CD40 Ligand (CD40LG)

Type de proteíne

Recombinant

Activité biologique

Active

Origine

Humain

Source

Escherichia coli (E. coli)

Pureté

< 98 % by SDS-PAGE gel and HPLC analyses.

Discover our top product CD40LG Protéine

Attributs du protein

Soluble

Séquence

MQKGDQNPQI AAHVISEASS KTTSVLQWAE KGYYTMSNNL VTLENGKQLT VKRQGLYYIY AQVTFCSNRE ASSQAPFIAS LWLKSPGRFE RILLRAANTH SSAKPCGQQS IHLGGVFELQ PGASVFVNVT DPSQVSHGTG FTSFGLLKL

Attributs du produit

Assay 1: Determined by the stimulation of IL - 12 induction by human PBMCs.
Assay 2: Determined by the dose - dependent stimulation of IL - 8 production by human PBMC. The expected ED50 for this effect is 5 - 10 ng/mL. Note: Results may vary with PBMC donors.

niveau d'endotoxine

Endotoxin level is less than 0.1 ng per μg (1 EU/μg).

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Produit

Système d'expression

Conjugué

Origin

Prix à partir de

CD40 Ligand Protein (CD40LG) (AA 1-261) (His tag)

Système d'expression HEK-293 Cells

Conjugué His tag

Origin Human

Prix à partir de 16.256,82 €

CD40 Ligand Protein (CD40LG) (AA 1-261) (Strep Tag)

Système d'expression Cell-free protein synthesis (CFPS)

Conjugué Strep Tag

Origin Human

Prix à partir de 20.480,57 €

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CD40 Ligand (CD40LG) (AA 113-261), (Trimer) protein (Fc Tag)
CD40LG Origine: Humain Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD40 Ligand (CD40LG) (AA 113-261), (Trimer) protein (His-DYKDDDDK Tag,Biotin)
CD40LG Origine: Humain Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD40 Ligand (CD40LG) (AA 113-261), (Trimer) protein (His-DYKDDDDK Tag)
CD40LG Origine: Humain Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

CD40 Ligand (CD40LG) (AA 1-260) protein (His tag)
custom-made CD40LG Origine: Souris Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

CD40 Ligand (CD40LG) (AA 1-261) protein (His tag)
custom-made CD40LG Origine: Humain Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

CD40 Ligand (CD40LG) (AA 112-260), (Trimer) protein (Fc Tag)
CD40LG Origine: Souris Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE

CD40 Ligand (CD40LG) (AA 116-261) protein (His-DYKDDDDK-Strep II Tag)
CD40LG Origine: Humain Hôte: HEK-293T Cells Recombinant SDS, WB, ELISA, PI

CD40 Ligand (CD40LG) (AA 113-261) (Active) protein (Fc Tag)
CD40LG Origine: Humain, Macaque rhésus Hôte: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active

CD40 Ligand (CD40LG) (AA 116-261) (Active) protein (DYKDDDDK Tag,His tag)
CD40LG Origine: Humain Hôte: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active

CD40 Ligand (CD40LG) protein
CD40LG Origine: Humain Hôte: Human Cells Recombinant >90 % as determined by reducing SDS-PAGE.

Restrictions

For Research Use only

Format

Lyophilized

Conseil sur la manipulation

As with any protein, exposing sCD40 Ligand recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Stock

-20 °C

Stockage commentaire

The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted sCD40 Ligand is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.

Date de péremption

24 months

Antigène

CD40 Ligand (CD40LG)

Autre désignation

CD40 Ligand

Sujet

CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. The human CD40L gene codes for a 261 amino acid type II transmembrane protein, which contains a 22 amino acid cytoplasmic domain, a 24 amino acid transmembrane domain, and a 215 amino acid extracellular domain. The soluble form of CD40L is an 18 kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L. Recombinant human soluble CD40 ligand is a 16.3 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CD40L.

ID gène

959

NCBI Accession

NP_000065

OMIM

4557433

UniProt

P29965

Pathways

Signalisation NF-kappaB, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints